Exciting Monday news – a new Carroll Lab paper has officially been published! In collaboration with Dr. Ajay Gulati’s lab, Dr. Steven Lichtman, and the team at OpenBiome, we present a compelling case report of a pediatric patient with recurrent D-lactic acidosis that was resolved after a fecal microbiota transplant (FMT) in the Journal of Pediatric Gastroenterology and Nutrition. We also analyzed the bacterial composition and D/L-lactic acid abundance in her stool before and after FMT, allowing us to raise some new ideas about the pathophysiology of this disorder. D-lactic acidosis is driven by metabolic activity of colonic bacteria, and one of the hallmark symptoms is altered mental status…an interesting example of the microbiota-gut-brain axis at work. Take a look! https://journals.lww.com/jpgn/Fulltext/2018/10000/Intestinal_Microbial_and_Metabolic_Alterations.13.aspx

 

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